Ilaprazole: Is this a superior proton pump inhibitor for duodenal ulcer? | Semantic Scholar (2024)

Ilaprazole is a highly effective and safe PPI in the treatment of duodenal ulcers and can be recommended as a therapy for acid-related disorders, especially in Asian populations.

A high dose of ilaprazole + amoxicillin was ineffective as the first-line therapy for eradicating H. pylori in Korea and future studies should focus on intragastric pH measurements and assess am toxicillin resistance.

The results of this investigation indicated no statistically significant differences between the logarithmic transformed AUC 0-͵ and C max values of the two preparations and support the use of the 10 mg dose tablet newly formulated.

High concentration of [125I]iodoilaprazole in stomach ulcers makes this compound a promising new radiotracer for stomach ulcer imaging.

Ilaprazole is as tolerable, safe, and efficacious as omeprazole in the treatment of duodenal ulcers, especially at a lower dose (10 mg/d ilaprazoles vs. 20mg/d omepazole).

Ilaprazole is as effective as omeprazole (20 mg/d) in the treatment of DU with similar side effects and the efficacy is not affected by CYP2C19 polymorphisms.

PPIs have changed the face of GORD in the new millennium as the focus in gastroenterology practice has shifted to primarily treating patients who fail PPI therapy.

Ilaprazole is as tolerable, safe, and efficacious as omeprazole in the treatment of gastric and duodenal ulcers, at a much lower dose (5 vs. 20mg omEPrazole).

Ilaprazole has a strong effect on intragastric acid control with a dose dependent trend in duodenal ulcer patients.

Although they share a common core structure and mechanism of action, it is important to understand the general pharmacology of these agents and how they differ from histamine2‐receptor antagonists in order to optimize PPI therapy.

It is suggested that IY81149 is comparable with omeprazole in the treatment of reflux oesophagitis and dose-dependently prevented lipid peroxidation.

IY-81149 revealed the characteristics as a strong proton pump inhibitor, and its potency against gastric acid secretion was superior to that of the reference drug, omeprazole.

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