Identification of IY81149 and its metabolites in the rat plasma using the on-line HPLC/ESI mass spectrometry | Semantic Scholar (2024)

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@article{Myung1999IdentificationOI, title={Identification of IY81149 and its metabolites in the rat plasma using the on-line HPLC/ESI mass spectrometry}, author={Seung-woon Myung and H K Min and Changbae Jin and Myungsoo Kim and Seung Mok Lee and Gi Ju Chung and Seong Jun Park and Dong Yeon Kim and Hyun-Woo Cho}, journal={Archives of Pharmacal Research}, year={1999}, volume={22}, pages={189-193}, url={https://api.semanticscholar.org/CorpusID:32762496}}
  • S. Myung, H. Min, Hyun-Woo Cho
  • Published in Archives of pharmacal… 1 April 1999
  • Chemistry, Medicine

Reversed-phase high-performance liquid chromatography/mass spectrometry (HPLC/MS) with an electrospray ionization (ESI) interface was applied to the identification of metabolites of IY 81149 in the…

18 Citations

Highly Influential Citations

1

Background Citations

6

Methods Citations

1

18 Citations

Identification of ilaprazole metabolites in human urine by HPLC-ESI-MS/MS and HPLC-NMR experiments.
    Gan ZhouS. Shi J. Tan

    Medicine, Chemistry

    Biomedical chromatography : BMC

  • 2010

The structural elucidation of urinary metabolites of ilaprazole in human was described byHPLC-ESI-MS/MS and stopped-flow HPLC-NMR experiments and testified that HPLCs and NMR could be widely applied in detection and identification of novel metabolites.

Identification of the New In Vivo Metabolites of Ilaprazole in Rat Plasma after Oral Administration by LC-MS: In Silico Prediction of the H+/K+-ATPase Inhibitor
    Guiqiu ZhangKaijing GuoPengfei WangYin ShanChen Ma

    Chemistry, Medicine

    Molecules

  • 2021

The result of the in silico prediction indicates that all the new metabolites of ilaprazole showed the potential ability to inhibit H+/K+-ATPase activity.

An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmaco*kinetic study
    Gan ZhouZ. Tan H. Deng

    Chemistry, Medicine

    Acta Pharmacologica Sinica

  • 2009

This method was successfully applied for the evaluation of the pharmaco*kinetics of ilaprazole and its two metabolites after single oral doses of 5 mg ilapazole to 12 healthy Chinese volunteers and offered sensitivity and a wide linear concentration range.

  • 29
  • PDF
Improved liquid chromatography-mass spectrometry performance in quantitative analysis using a nanosplitter interface.
    C. AndrewsChung-Ping YuEric YangP. Vouros

    Chemistry, Medicine

    Journal of chromatography. A

  • 2004
  • 21
SIMULTANEOUS DETERMINATION OF ILAPRAZOLE AND ITS RELATED COMPOUNDS IN PHARMACEUTICAL DOSAGE FORMS BY UPLC
    B. SatheeshK. K. Sree GaneshD. SaravananK. Gundu RamakantS. Sivananthan

    Chemistry, Medicine

  • 2013

A stability indicating UPLC method was developed and validated for simultaneous determination of Ilaprazole and its impurities in tablets and the calibration curves obtained for the five impurities were linear over the range 0.05 to 0.60 µg/mL.

  • 13
Biotransformation of Ilaprazole in Human Liver Microsomes and Human: Role of CYP3A4 in Ilaprazole Clearance and Drug-Drug Interaction
    Jie PuFen WangWei TangM. Zhu

    Medicine, Chemistry

    Drug Metabolism and Disposition

  • 2018

It is proposed that nonenzymatic sulfoxide reduction rather than CYP3A4-medidated sulfoxide oxidation is the major metabolic clearance pathway of ilaprazole in humans, and it is predicted that ilapazole has no significant drug-drug interaction via CYP 3A4 inhibition or induction by a coadministered drug.

  • 12
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ILAPRAZOLE IN PHARMACEUTICAL DOSAGE FORMS
    S. S. PatilS. PatilR. S. WaghShree Sureshdada

    Chemistry, Medicine

  • 2014

A simple, rapid, accurate and precise RP-HPLC method was developed and validated for the estimation of Ilaprazole in pharmaceutical dosage form and was shown to be linear over a range of 5-25 µgm/ml.

Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5
    Kyung-ah SeoSo‐Jeong Lee Jae-Gook Shin

    Chemistry, Medicine

    Xenobiotica; the fate of foreign compounds in…

  • 2012

Results indicate that the formation of the major metabolite of ilaprazole, ilapazole sulfone, is predominantly catalysed by CYP3A4/5.

  • 29
Investigation on the interaction between ilaprazole and bovine serum albumin without or with different C-ring flavonoids from the viewpoint of food-drug interference.
    Yuping ZhangS. ShiXiaoqing ChenWei ZhangKe‐long HuangMijun Peng

    Agricultural and Food Sciences, Chemistry

    Journal of agricultural and food chemistry

  • 2011

The interaction between ilaprazole and bovine serum albumin (BSA) has been investigated in the absence and presence of four popular flavonoids with different C-ring structures, quercetin, luteolin,…

  • 70
Ilaprazole metabolites, ilaprazole sulfone and ilaprazole sulfide decreased the affinity of ilaprazole to bovine serum albumin
    W. ZhuangLi LiGuoqiang LinZhenyu DengMijun Peng

    Chemistry

  • 2012
  • 15

...

...

9 References

The structural identification of drug metabolites using thermospray liquid chromatography/mass spectrometry.
    I. BeattieT. Blake

    Chemistry, Medicine

  • 1989

The examples discussed in this paper illustrate the value of LC/MS in identifying unknown drug metabolites covering a wide polarity range in a complex biological mixture, if the interface had been unable to handle gradient separations.

  • 16
Studies on the metabolism of omeprazole in the rat using liquid chromatography/ionspray mass spectrometry and the isotope cluster technique with [34S]omeprazole.
    L. WeidolfT. Covey

    Chemistry, Medicine

    Rapid communications in mass spectrometry : RCM

  • 1992

This paper describes the application of the ionspray (pneumatically-assisted electrospray) interface for liquid chromatography (LC) and atmospheric-pressure ionization mass spectrometry (API MS) to…

  • 28
High-performance liquid chromatographic assay for human liver microsomal omeprazole metabolism.
    T. AnderssonP. LagerstromJ. MinersM. E. VeroneseL. WeidolfD. Birkett

    Chemistry, Medicine

    Journal of chromatography

  • 1993
  • 21
Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed-phase high-performance liquid chromatography with an alkaline-resistant polymer-coated C18 column.
    Kaoru KobayashiK. ChibaD. SohnY. KatoT. Ishizaki

    Medicine, Chemistry

    Journal of chromatography

  • 1992
  • 71
Reflections on the analytical pharmacology of histamine h2-receptor antagonists.
    James Black

    Chemistry, Medicine

    Gastroenterology

  • 1993
  • 44
  • PDF
Omeprazole. An update of its pharmacology and therapeutic use in acid-related disorders.
    M. WildeD. McTavish

    Medicine

    Drugs

  • 1994

Omeprazole plus amoxicillin appears to be better tolerated than triple therapy and represents a first-line treatment alternative in patients with H. pylori-associated peptic ulcer disease.

  • 211
Omeprazole: effective, convenient therapy for Zollinger-Ellison syndrome.
    Katherine E. McArthurM. J. Collen J. D. Gardner

    Medicine

    Gastroenterology

  • 1985
  • 121
United States patent
    Robert J. GustafsonMarty A. GustafsonBrant C. White

    Engineering

  • 1985

Texte d'un brevet des Etats-Unis concernant une methode d'elimination de la silice des eaux geothermiques

  • 1,863
  • PDF
Omeprazole: The first proton pump inhibitor
    P. LindbergA. BrändströmB. WallmarkH. MattssonL. RiknerK. Hoffmann

    Chemistry, Medicine

    Medicinal research reviews

  • 1990
  • 187
  • PDF

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